3 In addition, Starup et al have found that there is an association between SOST and fracture risk in diabetic patients, suggesting that SOST might play a significant role in the regulation of glucose and bone metabolism, 6 but the role that SOST plays in this is less clear and requires subsequent in-depth study. A study aiming to explore the relationship between serum SOST and the risk of T2DM shows there is a weak positive correlation between SOST and fasting glucose.

4 SOST is a major inhibitor of the Wnt signaling pathway.

3–5 The Wnt signaling pathway plays a valuable role in bone metabolism and other metabolic diseases. In addition, the incidence of OP in aging postmenopausal women is even three times higher than that in men of the same age. 1, 2 The prevalence of OP in patients with T2DM can range from 30% to 60%. The characteristic of osteoporosis (OP) is loss of bone mineral mass, leading to an increased risk of bone fractures and a decreased bone mineral density. Type 2 diabetes mellitus (T2DM) is a chronic systemic metabolic disease. Keywords: SOST gene polymorphism, gene mutation, type 2 diabetes mellitus, osteoporosis, bone mineral density, SOST protein 5) Multiple linear regression analysis for BMD-dependent variables showed that the decrease of BMI and TG were risk factors for BMD (L1-4), besides, the decrease of BMI, ALP, and extended years of menopause were all risk factors for BMD (femoral neck).Ĭonclusion: SOST protein expression and genetic locus rs851056, rs1230399 polymorphism are associated with bone mineral density in postmenopausal women with type 2 diabetes mellitus in Xinjiang. BMD (L1-4) was negatively correlated with SOST protein. 3) SOST protein expression levels were higher in groups C and D than in group A. In contrast, individuals carrying the GG genotype had higher BMD (L1-4) as compared to those carrying the GC/CC genotypes in group D. 2) Individuals carrying the GG genotype had lower HDL, Ca, and ALP as compared to those carrying the GC/CC genotypes in group C. Results: 1) Genotypes and allele frequencies at rs851056 were statistically significant differences in groups B and D patients compared to group A, respectively. Genetic polymorphisms were determined using the mass ARRAY mass spectrometer. Methods: A total of 136 Xinjiang postmenopausal women were divided into four groups: A (-/-), B (±), C (-/+), and D (+/+) by assessing their OGTT and bone mass. Objective: This study aims to explore whether SOST protein expression and genetic locus rs851056, rs1230399 polymorphism is associated with bone mineral density in postmenopausal women with T2DM in Xinjiang. The expression of SOST and genetic polymorphism might be associated with bone mineral density in postmenopausal women with type 2 diabetes mellitus (T2DM). SOST is a major inhibitor of the Wnt signaling pathway. *These authors contributed equally to this workĬorrespondence: Jun Li Email īackground: The Wnt signaling pathway plays a valuable role in bone metabolism. Jun Li, 1, * YanXia Ren, 1, * SiYuan Li, 2 JiaJia Li 3ġEndocrinology and Metabolism Department, First Affiliated Hosptital, School of Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China 2Shihezi University School of Medicine, Shihezi, Xinjiang Uygur Autonomous Region, People’s Republic of China 3Endocrinology and Metabolism Department, Second People’s Hospital of Nanyang, Nanyang, Henan Province, People’s Republic of China

Sims 4 ethnic cc